Convenient method to induce orofacial dyskinesia: a novel animal model of tardive dyskinesia

Tardive dyskinesia is hyperkinetic movement disorder in which repetitive involuntary movements. Preclinical studies for tardive dyskinesia require use of large amount of animals. In order to reduce animal use, principle of refinement is used in the present research. Albino rats were used as animal model. Different drugs were used to induce orofacial dyskinesia. Locomotor activity, open field activity and motor co-ordination were also studied for all the drugs and their neuroprotective effects were evaluated using this new model.